20S Immunoproteasome Antibodies

Antibodies that detect 20S Immunoproteasome can be used in several scientific applications, including Immunocytochemistry and Immunohistochemistry. These antibodies target 20S Immunoproteasome in Human samples. Our 20S Immunoproteasome monoclonal antibodies are... Antibodies that detect 20S Immunoproteasome can be used in several scientific applications, including Immunocytochemistry and Immunohistochemistry. These antibodies target 20S Immunoproteasome in Human samples. Our 20S Immunoproteasome monoclonal antibodies are developed in Mouse. Find the 20S... Antibodies that detect 20S Immunoproteasome can be used in several scientific applications, including Immunocytochemistry and Immunohistochemistry. These antibodies target 20S Immunoproteasome in Human samples. Our 20S Immunoproteasome monoclonal antibodies are developed in Mouse. Find the 20S Immunoproteasome antibody that fits your needs. Choose from 1 of 2 20S Immunoproteasome antibodies, which have been validated in experiments with 2 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody... Antibodies that detect 20S Immunoproteasome can be used in several scientific applications, including Immunocytochemistry and Immunohistochemistry. These antibodies target 20S Immunoproteasome in Human samples. Our 20S Immunoproteasome monoclonal antibodies are developed in Mouse. Find the 20S Immunoproteasome antibody that fits your needs. Choose from 1 of 2 20S Immunoproteasome antibodies, which have been validated in experiments with 2 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

靶标信息

The 20S immunoproteasome is a specialized form of the proteasome complex that plays a crucial role in the immune system by processing intracellular proteins into peptides for presentation on major histocompatibility complex (MHC) class I molecules. This process is essential for the recognition of infected or malignant cells by cytotoxic T lymphocytes. The immunoproteasome is composed of unique catalytic subunits, including LMP2 (PSMB9), LMP7 (PSMB8), and MECL-1 (PSMB10), which replace their constitutive counterparts in the standard proteasome. These subunits enhance the generation of peptides that are optimal for MHC class I binding. The formation of the immunoproteasome is induced by inflammatory cytokines such as interferon-gamma (IFN-gamma), which are released during immune responses to infections or tumors. Beyond its role in antigen presentation, the immunoproteasome also contributes to the regulation of cytokine production and the maintenance of protein homeostasis under stress conditions. Dysregulation or mutations in the components of the immunoproteasome have been implicated in various autoimmune diseases, such as lupus and rheumatoid arthritis, as well as in certain cancers. Understanding the function and regulation of the 20S immunoproteasome is important for developing therapeutic strategies aimed at modulating immune responses, enhancing cancer immunotherapy, and treating autoimmune disorders.